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Revealing the role of the human blood plasma proteome in obesity using genetic drivers
2021
Nature Communications
AbstractBlood circulating proteins are confounded readouts of the biological processes that occur in different tissues and organs. Many proteins have been linked to complex disorders and are also under substantial genetic control. Here, we investigate the associations between over 1000 blood circulating proteins and body mass index (BMI) in three studies including over 4600 participants. We show that BMI is associated with widespread changes in the plasma proteome. We observe 152 replicated
doi:10.1038/s41467-021-21542-4
pmid:33627659
pmcid:PMC7904950
fatcat:hftdlrtqjfcjtc2ojuwb3dpmaa