Drug-related osteonecrosis of the jaw (MRONJ) is a drug complication characterized by the progressive destruction and necrosis of the bone, in the absence of previous radiation treatment. In the present report, a 58-year-old cancer patient treated with zolendronic acid developed a spontaneous palatal osteonecrosis. Following repeated courses of antibiotic therapy, there was no improvement of the osteonecrosis. Subsequently, after several attempts, an integrum healing occurred with the use of an

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... 810 nm diode laser at 3.5 W and 10% povidone iodine as photosensitizer, with the addition of 0.330 g of acetylsalicylic acid. and 0.200 g of vitamin C as a final rinse. Therefore, the aim of our work is to illustrate the resolution of a spontaneous maxillary ONJ with this particular PDT. Background: Drug-related osteonecrosis of the jaw (MRONJ) is a potentially serious and debilitating drug-related complication. It consists in the progressive bone destruction in the maxillofacial area of patients exposed to treatment with drugs associated with the risk of ONJ, in the absence of previous radiation therapy. The treatment involves the application of well-defined therapeutic ministerial protocols, however, there are numerous cases of relapse and incomplete remission of MRONJ. In the literature there are many alternative therapeutic options for the management and prevention of MRONJ, in particular, photodynamic therapy (PTD) is increasingly used with very positive outcomes [1] [2] [3] [4] [5] . Therefore, the aim of our work is to illustrate the resolution of a spontaneous maxillary ONJ with a particular PDT.