Objective: To study the effect of TSLC1 overexpression by adenovirus on proliferation, invasion and angiogenesis of cervical cancer cells. Methods: Caski cervical cancer cells were cultured and divided into blank control group, Ad-RFP group and Ad-TSLC1 group that were treated with DMEM without adenovirus or serum, control adenovirus Ad-RFP and TSLC1-overexpressed recombinant adenovirus Ad-TSLC1 respectively. 12 h and 24 h later, the expression of proliferation, invasion, angiogenesis genes

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... determined respectively. Results: HERC4, CyclinD1, Bcl-2, S100A6, N-cadherin, Snail, Twist, EFEMP1, VEGF and Jagged1 mRNA expression in Ad-TSLC1 group were significantly lower than those in control group and Ad-RFP group; HERC4, CyclinD1, Bcl-2, S100A6, N-cadherin, Snail, Twist, EFEMP1, VEGF and Jagged1 mRNA expression in Ad-RFP group were not significantly different from those in control group. Conclusion: TSLC1 overexpression by adenovirus can inhibit the proliferation, invasion and angiogenesis of cervical cancer cells.