Objective: The aim of present study was the Synthesis and characterization of Azoles Based Benzoic Acid Derivative. Materials and Methods: The compounds were prepared by reaction of Benzoic Acid with thiosemicarbazide in the presence of Phosphorus oxychloride to yield 1, 3, 4-thiadiazole nucleus. Further this thiadiazole was treated with different aromatic aldehydes in presence of methanol to yield corresponding Schiff's bases. All the Schiff's bases thus obtained were reacted with Thioglycolic

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... acid to yield the title compounds. Synthesized derivatives were characterized by IR, H NMR and screened for their antibacterial ( ) and antifungal 1 S. aureus, B. subtilis, E. coli, and P. aerugiosa activity (A. Niger and C. albicans). The experimental data of present research work reveals Results and conclusion: that the synthesized azole derivative (1, 2, 9, and 11) demonstrates significant Antibacterial and Antifungal Activity as shown in table no. 1and out of all synthesized compounds the halogen substituted thiazolidinones derivatives are found most active.