Objective: To study the outcome of children hospitalized with community acquired pneumonia treated with aqueous penicillin G. Design: Prospective study. Setting: The study was conducted in Belagavi Institute of Medical Sciences, a referral hospital during 2014-2015. Children aged from more than 2 months to 18yrs of age were studied. Total of 84 children who met the inclusion criteria were studied. Eligible children were given injection crystalline penicillin 2 lakh IU/kg in four divided doses

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... ter drug sensitivity testing. Children were assessed every 12 th hourly, for respiratory rate, pulse rate, blood pressure and signs of respiratory distress. In case of worsening of symptoms, persistence of tachynpea, fever, till 48 hours, antibiotic was changed. The study was conducted to know the proportion of children with community acquired pneumonia who responded to crystalline penicillin injection. Results: Out of 84 children treated with crystalline penicillin 79 responded, antibiotic was changed for the other 5 children. 3 boys out of 48 and 2 girls out of 36 did not respond to crystalline penicillin. 2 out of 24 children in the age group of 2-12 months, 3 out of 33 in the 1-5 yrs, did not respond to crystalline penicillin. Persistence of tachypnea at the end of 48 hours was the indication for change of change of antibiotics in 5 children. No adverse outcome was noted. The mean duration of stay in the hospital among the studied children was 7 days (6.93±1.28). Conclusion: Injection crystalline penicillin effectively cures and is apt to be used as a first line antibiotic in treating hospitalized children with community acquired pneumonia.