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Inferring parameters of the distribution of fitness effects of new mutations when beneficial mutations are strongly advantageous and rare
[article]
2019
bioRxiv
pre-print
AbstractCharacterising the distribution of fitness effects (DFE) for new mutations is central in evolutionary genetics. Analysis of molecular data under the McDonald-Kreitman test has suggested that adaptive substitutions make a substantial contribution to between-species divergence. Methods have been proposed to estimate the parameters of the distribution of fitness effects for positively selected mutations from the unfolded site frequency spectrum (uSFS). However, when beneficial mutations
doi:10.1101/855411
fatcat:ffnwv56czngmfoodisoigzrlzq