In the context of the digital age and innovation-driven strategies, the rapid development of the e-commerce economy has had a significant impact on regional enterprise innovation. This paper collects the panel data of 30 provinces (municipalities and autonomous regions) in the country from 2013 to 2020 and uses the fixed effect model to test the e-commerce business from three aspects: Internet penetration rate, information transaction technology level, and enterprise information technology

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... using Stata software. The impact of economic development on regional enterprise innovation, and the possible location heterogeneity between eastern, central, and western regions of China was further studied. Finally, it was concluded that the development of the e-commerce economy in different regions had an impact on enterprise innovation. The degree of positive impact varies, and research implications are summarized from the corporate and government levels.