A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is
Graphical Abstract Highlights d TNFR2 has opposing functions in microglia and monocytes/ macrophages in EAE d Microglial TNFR2 mediates protective responses at EAE onset d Monocyte/macrophagic TNFR2 is detrimental in EAE by driving autoimmune activation SUMMARY In multiple sclerosis (MS), soluble tumor necrosis factor (TNF) is detrimental via activation of TNF receptor 1 (TNFR1), whereas transmembrane TNF is beneficial primarily by activating TNF receptor 2 (TNFR2). Here, we investigate thedoi:10.1016/j.celrep.2016.11.083 pmid:28052249 pmcid:PMC5218601 fatcat:fncru4tgcnddxdtkfjo4sfna6e