T Cell Epitope Predictions

Bjoern Peters, Morten Nielsen, Alessandro Sette
2020 Annual Review of Immunology  
Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of essentially all cell types. MHC ligands that trigger a T cell immune response are referred to as T cell epitopes. Identifying such epitopes enables tracking, phenotyping, and stimulating T cells involved in immune responses in infectious disease, allergy, autoimmunity, transplantation, and cancer. The specific T cell epitopes recognized in an individual are determined by genetic factors such as the MHC molecules
more » ... he individual expresses, in parallel to the individual's environmental exposure history. The complexity and importance of T cell epitope mapping has motivated the development of computational approaches that predict what T cell epitopes are likely to be recognized in a given individual or in a broader population. Such predictions guide experimental epitope mapping studies and enable computational analysis of the immunogenic potential of a given protein sequence region. Expected final online publication date for the Annual Review of Immunology, Volume 38 is April 26, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
doi:10.1146/annurev-immunol-082119-124838 pmid:32045313 fatcat:x5z4f7equvbkldtzj6m7inxxsy