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Reduced antibody activity against SARS-CoV-2 B.1.617.2 Delta virus in serum of mRNA-vaccinated patients receiving TNF-alpha inhibitors [article]

Rita E Chen, Matthew J Gorman, Daniel Y Zhu, Juan Manuel Carreno, Dansu Yuan, Laura A VanBlargan, Samantha Burdess, Douglas A Lauffenburger, Wooseob Kim, Jackson S Turner, Lindsay Droit, Scott A Handley (+11 others)
2021 medRxiv   pre-print

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https://web.archive.org/web/20220802164323/https://www.medrxiv.org/content/medrxiv/early/2021/09/29/2021.09.28.21264250.full.pdf

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Although vaccines effectively prevent COVID-19 in healthy individuals, they appear less immunogenic in individuals with chronic inflammatory diseases (CID) and/or under chronic immunosuppression, and there is uncertainty of their activity against emerging variants of concern in this population. Here, we assessed a cohort of 74 CID patients treated as monotherapy with chronic immunosuppressive drugs for functional antibody responses in serum against historical and variant SARS-CoV-2 viruses
more » ... immunization with Pfizer mRNA BNT162b2 vaccine. Longitudinal analysis showed the greatest reductions in neutralizing antibodies and Fc effector function capacity in individuals treated with TNF-alpha inhibitors, and this pattern appeared worse against the B.1.617.2 Delta virus. Within five months of vaccination, serum neutralizing titers of the majority of CID patients fell below the presumed threshold correlate for antibody-mediated protection. Thus, further vaccine boosting or administration of long-acting prophylaxis (e.g., monoclonal antibodies) likely will be required to prevent SARS-CoV-2 infection in this susceptible population.
doi:10.1101/2021.09.28.21264250 fatcat:ehphchuyerci3b6w2vspjinjlm
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Rita E Chen, Matthew J Gorman, Daniel Y Zhu, Juan Manuel Carreno, Dansu Yuan, Laura A VanBlargan, Samantha Burdess, Douglas A Lauffenburger, Wooseob Kim, Jackson S Turner, Lindsay Droit, Scott A Handley, Salim Chahin, Parakkal Deepak, Jane O'Halloran, Michael Paley, Rachel Presti, Gregory F Wu, Florian Krammer, Galit Alter, Ali Ellebedy, Alfred Hyoungju Kim, Michael S Diamond. "Reduced antibody activity against SARS-CoV-2 B.1.617.2 Delta virus in serum of mRNA-vaccinated patients receiving TNF-alpha inhibitors." medRxiv (2021)