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Novel conopeptides of the I-superfamily occur in several clades of cone snails
2004
Toxicon
The I-superfamily of conotoxins represents a new class of peptides in the venom of some Conus species. These toxins are characterized by four disulfide bridges and inhibit or modify ion channels of nerve cells. When testing venoms from 11 Conus species for a functional characterization, blocking activity on potassium channels (like Kv1.1 and Kv1.3 channels, but not Kv1.2 channels) was detected in the venom of Conus capitaneus, Conus miles, Conus vexillum and Conus virgo. Analysis at the cDNA
doi:10.1016/j.toxicon.2004.07.006
pmid:15450929
fatcat:ynic36hcijalrcukxmejhqgnsy