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On the evolution of cellular senescence
2020
Aging Cell
The idea that senescent cells are causally involved in aging has gained strong support from findings that the removal of such cells alleviates many age-related diseases and extends the life span of mice. While efforts proceed to make therapeutic use of such discoveries, it is important to ask what evolutionary forces might have been behind the emergence of cellular senescence, in order better to understand the biology that we might seek to alter. Cellular senescence is often regarded as an
doi:10.1111/acel.13270
pmid:33166065
fatcat:62irsaodbjhmppym5njqcvdcwy