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Ig H chain variable and C region genes in common variable immunodeficiency. Characterization of two new deletion haplotypes
1991
Journal of Immunology
Common variable immunodeficiency, a disorder characterized by diminished antibody production, manifests clinically as an increased susceptibility to bacterial infections. We have investigated the Ig H chain V and C region gene segments in 33 patients with common variable immunodeficiency, to identify the possible role these genes may have in the molecular basis of the defect. No major deletions were recognized for the VH gene segments of the VH2, VH5, and VH6 families, nor were there any
doi:10.4049/jimmunol.147.8.2540
fatcat:sudwj7uphfas3k2wwkktrf22f4