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Synthetic lethality (SL) is a novel strategy for anticancer therapies, whereby mutations of two genes will kill a cell but mutation of a single gene will not. Therefore, a cancer-specific mutation combined with a drug-induced mutation, if they have SL interactions, will selectively kill cancer cells. While numerous SL interactions have been identified in yeast, only a few have been known in human. There is a pressing need to systematically discover and understand SL interactions specific todoi:10.1109/bibm.2013.6732609 dblp:conf/bibm/LiMWZZ13 fatcat:i6fm7smh4ngaxdw72ahwfatfja