The integration of distributed renewable energy sources and the multi-domain behaviours inside the cyber-physical energy system (smart grids) draws up major challenges. Their validation and roll out requires careful assessment, in term of modelling, simulation and testing. The traditional approach focusing on a particular object, actual hardware or a detailed model, while drastically simplifying the remainder of the system under test, is no longer sufficient. Real-time simulation and

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... -the-Loop (HIL) techniques emerge as indispensable tools for validating the behaviour of renewable sources as well as their impact/interaction to with the cyber-physical energy system. This paper aims to provide an overview of the present status-quo of real-time and HIL approaches used for smart grids and their readiness for cyber-physical experiments. We investigate the current limitations of HIL techniques and point out necessary future developments. Subsequently, the paper highlights challenges that need specific attention as well as ongoing actions and further research directions.