Glycemic Index of three Oral Nutritional Supplements in healthy adults: a single-blind crossover study
Background: The main objective of this study was to evaluate the glycemic index (GI) and insulin index (II) of three oral nutritional supplements (ONS) in healthy adults. Methods: A single-blind crossover study was conducted in 12 healthy adults. Fasted subjects consumed one of three treatments at each visit, with a one week wash out period between visits. Every subject received all treatments. Treatments included two newly developed ONS (powder A, powder B) as well as a positive control Nutren
... tive control Nutren ® Diabetes (powder C). Blood glucose and insulin levels at 15, 30, 45, 60, 90, 120, 180 and 240 mins were measured after the volunteers consumed one of the treatments which all of containing 50g carbohydrates per serving. The Wolever method was used to compute the area under the curve (AUC) for blood glucose and insulin, and GI and II of three powders were obtained. Results: Using the GI and II of 50g glucose powder as reference standard, the GI of nutrition powders A, B and C are 44, 54, 29, respectively, and the II of nutrition powders A, B and C are 163, 182, 119, respectively. Conclusions: Among the two newly developed ONS formulas, powder A is more suitable as an ONS for diabetics.Trial registration: This trial was registered on www.chictr.org.cn as ChiCTR2000031287 on 03/26/2020.