Latent Hypoparathyroidism in an Osteoporotic Patient with Multiple Endocrinopathies and Secondary Hemochromatosis due to Multiple Blood Transfusions, Unmasked by Alendronate and Glucocorticoid at Adrenal Crisis

Keiji Tanimoto, Yumiko Okubo, Chie Harada, Hiroshi Saito, Akira Sata, Aiko Nishikawa, Rina Ohwada, Mika Tsuiki, Masaaki Yamamoto, Etsuko Hashimoto, Kanji Sato, Kazue Takano
2008 Internal medicine (Tokyo. 1992)  
A 30-year-old normocalcemic man with hypopituitarism, hypogonadism, diabetes mellitus, and secondary hemochromatosis due to multiple blood transfusions was admitted because of adrenal crisis. After intravenous administration of saline and cortisol, the corrected serum level of calcium decreased to 7.3 mg/dl. This osteoporotic patient had been prescribed alendronate for radial bone fracture. Since the increase in intact PTH (68 pg/ml) was impaired compared to that seen in hypocalcemic patients
more » ... th secondary hyperparathyroidism, we presume that the patient has had latent hypoparathyroidism, which was unmasked by the administration of glucocorticoid and bisphosphonate. With a supplemented dose of 1α-OHD3, the patient has been eucalcemic. A 30-year-old normocalcemic man with multiple endocrinopathies, such as hypopituitarism, diabetes mellitus, and secondary hemochromatosis due to multiple blood transfu-
doi:10.2169/internalmedicine.47.0642 pmid:18344638 fatcat:izlo6pnykrbq5jhawqysxewd4y