Inhalation Studies of Uranium Trioxide

P. E. Morrow, F. R. Gibb, H. D. Beiter
1972 Health Physics  
Earlier injection and inhalation studies with uranium trioxide (UO,) indicated that the material was more similar to soluble uranyl salts than to the so-called insoluble oxides, U,Os and UO" but quantitative data were lacking. This inhalation study of UO, (enriched with 235U) in dogs substantiated the earlier studies with the findings that (a) UO, is rapidly removed from the lungs, with most following a 4.7 day biological half time; (b) systemic absorption amounted to more than 20% of the
more » ... an 20% of the exposure burden; and (c) more than 20% of the excreted uranium was found in the urine. External measurement of the UO, levels in the lungs (186 keV gamma) produced an erroneous picture of UO, clearance because of appreciable 235U accretion in the extrapulmonary structures of the thorax. The inhalation study was complemented by aerosol and in vitro solubility analyses in order to examine a recently-proposed solubility model for alveolar clearance. The health physics implications of the results are discussed.
doi:10.1097/00004032-197209000-00001 pmid:4642950 fatcat:prlygxwrevanrnijdvxy75krge