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The manipulation of organisms using combinations of gene knockout, RNAi and drug interaction experiments can be used to reveal regulatory interactions between genes. Several algorithms have been proposed that try to reconstruct the underlying regulatory networks from gene expression data sets arising from such experiments. Often these approaches assume that each gene has approximately the same number of interactions within the network, and the methods rely on prior knowledge, or thedoi:10.1049/ip-syb:20050092 pmid:16986626 fatcat:ews6vdpftjcqbiwjxd6buhysui