Analgesic and Anti-Inflammatory Activities of Leaf Extract ofMallotus repandus(Willd.) Muell. Arg

Md. Mahadi Hasan, Nizam Uddin, Md. Rakib Hasan, A. F. M. Mahmudul Islam, Md. Monir Hossain, Akib Bin Rahman, Md. Sazzad Hossain, Ishtiaque Ahmed Chowdhury, Md. Sohel Rana
2014 BioMed Research International  
In folk medicineMallotus repandus(Willd.) Muell. Arg. is used to treat muscle pain, itching, fever, rheumatic arthritis, snake bite, hepatitis, and liver cirrhosis. This study aimed to evaluate the antinociceptive as well as the anti-inflammatory activities of the methanol extract of leaf. The leaves were extracted with methanol following hot extraction and tested for the presence of phytochemical constituents. Analgesic and anti-inflammatory activities were evaluated using acetic acid induced
more » ... rithing test, xylene induced ear edema, cotton pellet induced granuloma, and tail immersion methods at doses of 500, 1000, and 2000 mg/kg body weight. The presence of flavonoids, saponins, and tannins was identified in the extract. The extract exhibited considerable antinociceptive and anti-inflammatory activities against four classical models of pain. In acetic acid induced writhing, xylene induced ear edema, and cotton pellet granuloma models, the extract revealed dose dependent activity. Additionally, it increased latency time in tail immersion model. It can be concluded thatM. repanduspossesses significant antinociceptive potential. These findings suggest that this plant can be used as a potential source of new antinociceptive and anti-inflammatory candidates. The activity of methanol extract is most likely mediated through central and peripheral inhibitory mechanisms. This study justified the traditional use of leaf part of this plant.
doi:10.1155/2014/539807 pmid:25629031 pmcid:PMC4297635 fatcat:f7gwm7ltkbbsjb2v36yt7qawcq