Associação dos biomarcadores com aterosclerose e risco para doença coronariana em portadores de HIV
Maria da Conceição Brandão de Arrud Falcão, Josefina Cláudia Zírpoli, Valéria Maria de Albuquerque, Brivaldo Markman Filho, Nelson Antônio Moura de Araújo, Creso Abreu Falcão, Demócrito de Barros Miranda-Filho, Ricardo Alencar de Arraes Ximenes, Maria de Fátima Militão de Albuquerque, Heloísa Ramos Lacerda
2012
Arquivos Brasileiros de Cardiologia
The massive use of Highly-Active Antiretroviral Therapy (HAART) in individuals with human immunodeficiency virus (HIV) coincided with an increase in cardiovascular disease, a major cause of morbidity and mortality in this group. Objective: To determine the frequency of carotid atherosclerosis and the association between biomarker levels and carotid intimal-medial thickening in HIV-positive individuals treated for HIV at referral centers in Pernambuco. Methods: This was a cross-sectional study
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... 122 HIV-positive patients. Subclinical carotid atherosclerosis was considered with the presence of increased intimal-medial thickness of the common carotid artery > 0.8 mm or plaques in the carotid ultrasound. The following inflammatory biomarkers were analyzed: IL6, IL1-β, TNF-α, high-sensitivity CRP, sVCAM-1 and sICAM-1. Results: Of the 122 patients analyzed, most were men (60.7%) aged > 40 years (57.4%) receiving HAART (81.1%). The prevalence of atherosclerosis was 42.6% (52 cases). Patients older than 40 years and intermediate or high Framingham score were more likely to develop atherosclerosis at the univariate analysis. Age older than 40 years (OR = 6.57, 95%CI: 2.66 to 16.2, p = 0.000), male gender (OR = 2.76, 95%CI: 1.12 to 6.79, p = 0.027) and presence of syndrome metabolic (OR = 2.27, 95%CI: 0.94 to 5.50, p = 0.070) were associated with atherosclerosis at the multivariate analysis. Elevated levels of inflammatory cytokines and adhesion molecules were not associated with the presence of atherosclerosis. Conclusion: There was no association between inflammatory biomarkers, adhesion molecules and presence of carotid atherosclerosis. However, a higher chance of subclinical atherosclerosis was observed in men, those older than 40 years, with intermediate / high Framingham score or metabolic syndrome. (Arq Bras Cardiol 2012;99(5):971-978)
doi:10.1590/s0066-782x2012005000093
pmid:23080223
fatcat:ihosqkep5zbb7azkpf23femcum
