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The Location of Regions in Guinea Pig and Bovine Myelin Basic Proteins Which Induce Experimental Allergic Encephalomyelitis in Lewis Rats
1975
Journal of Immunology
Myelin basic proteins and peptides derived from them by limited cleavage with pepsin were tested for their ability to induce experimental allergic encephalomyelitis (EAE) in Lewis rats. The encephalitogenicity of the weakly active bovine protein was found to be associated with both halves of the molecule, peptides (1–88) and (89–169). Of the four smaller derivatives of peptide (1–88), peptides (1–36), (43–88), (1–42), and (37–88), only the last two were active. This demonstrated that the
doi:10.4049/jimmunol.114.2_part_1.592
fatcat:yvx63qdpc5b6fjvzgq2jd6gl4a