Neural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal

Shelly S. Watkins, George F. Koob, Athina
2000 Nicotine & Tobacco Research  
The neurobiology of nicotine addiction is reviewed within the context of neurobiological and behavioral theories postulated for other drugs of abuse. The roles of various neurotransmitter systems, including acetylcholine, dopamine, serotonin, glutamate, gamma-aminobutyric acid, and opioid peptides in acute nicotine reinforcement and withdrawal from chronic administration are examined followed by a discussion of potential neuroadaptations within these neurochemical systems that may lead to the
more » ... velopment of nicotine dependence. The link between nicotine administration, depression and schizophrenia are also discussed. Finally, a theoretical model of the neurobiological mechanisms underlying acute nicotine withdrawal and protracted abstinence involves alterations within dopaminergic, serotonergic, and stress systems that are hypothesized to contribute to the negative affective state associated with nicotine abstinence.
doi:10.1080/14622200050011277 pmid:11072438 fatcat:6frdlcxhsrcs3krzwtzlg4j6mm