Context: Diabetes mellitus is a degenerative disease characterized by chronic hyperglycemia. Hyperglycemia is the cause of MDA levels increases due to damage to pancreatic beta cells. Regular physical exercise can improve insulin sensitivity. Soursop leaves are considered to have antioxidant effects. Aims: Here we aimed to prove the effectiveness of the soursop leaf extract and physical exercise could reduce blood glucose and MDA levels in diabetic rats. Settings and Design: The research method

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... was experimental using the pretest-posttest design with a control group in a completely randomized design. Methods and Material: Ammout 28 diabetic rats using Alloxan were divided into five groups: negative control, positive control, and treatment groups: Physical exercise, soursop leaves with the dose of 150 mg kg -1 , and a combination of both. The test was done by measuring MDA levels. Statistical analysis used: Data analysis of MDA levels was performed using one way ANOVA (α = 0.05) and description of pancreatic histology. Results: This study found that soursop leaf extract and moderate physical exercise of 20 m min -1 were able to reduce the MDA levels better than the combination treatment of both and positive control. The pancreatic histological picture shows inhibition of pancreatic beta-cell damage. Conclusions: In general, the result indicates that the administration of soursop leaf extract with the dose of 150 mg kg -1 BW -1 and physical exercise have a better antioxidant effect and can inhibit pancreatic damage in diabetic rat models. How to cite this article: Yulianti et al. (2020): Effects of soursop leaf extract and physical training on decreasing oxidative stress and pancreatic histopathology in diabetic rat models