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Social interaction is ubiquitous in human society. The two-person approach-a new, powerful tool to study information exchange and social behaviors-aims to characterize the behavioral dynamics and neural mechanisms of real-time social interactions. In this review, we discuss the benefits of two-person approaches compared to those for conventional, single-person approaches. We describe measures and paradigms that model social interaction in three dimensions (3-D), including eye-to-eye,doi:10.3389/fpsyt.2020.00301 pmid:32390881 pmcid:PMC7193689 fatcat:w3lvaos7r5gefnz2l5rj52al64