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Depletion of RUVBL2 in Human Cells Confers Moderate Sensitivity to Anticancer Agents
Journal of Cancer Science & Therapy
Many anticancer agents kill cancer cells by inducing lethal damage in DNA, but the capacity of DNA repair of cells reduce the therapeutic efficacy of anticancer agents. RuvB-like (RUVBL) 2 is part of large protein complexes such as TIP60 and INO80 that are involved in chromatin remodeling and DNA damage responses and repair. Relatively few studies have investigated the role of RUVBL2 in the survival of cells after exposure to anticancer agents. Methods: We depleted RUVBL2 in human MRC5-SV cellsdoi:10.4172/1948-5956.1000306 fatcat:rmbmx5ufe5bdzagbkyq7lbovei