Understanding the Physiology of the Blood-Brain Barrier: In Vitro Models

Gerald A. Grant, N. Joan Abbott, Damir Janigro
1998 Physiology  
Endothelial cells exposed to inductive central nervous system factors differentiate into a blood-brain barrier phenotype. The blood-brain barrier frequently obstructs the passage of chemotherapeutics into the brain. Tissue culture systems have been developed to reproduce key properties of the intact blood-brain barrier and to allow for testing of mechanisms of transendothelial drug permeation.
doi:10.1152/physiologyonline.1998.13.6.287 pmid:11390805 fatcat:vqkadnkn6rem7fuzmaueid7kje