The main objective of this study was to investigate the effect of LepidiumSativum powder (LSP) at concentration 2.5%, 5% and 10% in diet on CCL4-induced hepatotoxicity rats, gentamicin-induced nephrotoxicity rats and knowledge the organoleptic evaluation for bread and apple juice when supplement it.Forty-five adult male healthy albino rats (Sprague-Dawley strain)were divided into(9)groups.Weight of rats for all groups was nearly equal and each group contains 5 rats. Group(1)control negative

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... p in which normal rats were fed on basal diet and tap water. Group (2) hepatic control positive group in which hepatotoxicity rats which were injected by CCL4 were fed on basal diet and tap water. Group(3),(4)and(5)hepatic rats were fed on basal diet containing 2.5%, 5% and 10% LSP respectively. Group(6)nephritic control positive group in which nephrotoxicity rats which were injected by gentamicin were fed on basal diet and tap water. Group(7),(8)and(9)nephritic rats were fed on basal diet containing 2.5%, 5% and 10% LSP respectively. At the end of period of the experiment 28 day, rats were fasted 12 hours of diet and 2 hours of water, blood samples were collected from the retro orbital method by means of a micro capillary glass todetermine biochemical parameters as follows: aspartate aminotransaminase(AST or GOT),alanine aminotransferase (ALT or GPT), alkaline phosphatase (ALP), AST/ALT ratio,gammaglutamyltransferase (GGT), total protein (Tp), albumin (Alb), globulin (Glo), Alb /Glo ratio, total bilirubin (T.Bil), direct bilirubin(D.Bil), indirect bilirubin (Ind.