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In Vivo Dentate Nucleus Gamma-aminobutyric Acid Concentration in Essential Tremor vs. Controls
2017
Cerebellum
Background-Despite its high prevalence, essential tremor (ET) is among the most poorly understood neurological diseases. The presence and extent of Purkinje cell (PC) loss in ET is the subject of controversy. PCs are a major storehouse of central nervous system gamma-aminobutyric acid (GABA), releasing GABA at the level of the dentate nucleus. It is therefore conceivable that cerebellar dentate GABA concentration could be an in vivo marker of PC number. Objectives-We used in-vivo 1H magnetic
doi:10.1007/s12311-017-0891-4
pmid:29039117
fatcat:ltxhehilkrgs7kmvmkyguilyma