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Breast Cancer - From Biology to Medicine
Splicing is a critical step in gene expression, responsible for the excision of introns, producing the mature form of mRNA. Also, the possible arrangements of exons enlarge the proteome in 80%, enabling one gene to encode more than one protein isoform, thus increasing proteome. Growing data show deregulation of splicing events in cancer, being breast cancer the most studied. This aberrant pattern of splicing has an important role in breast tumor progression. These alterations are mainly causeddoi:10.5772/66162 fatcat:sxrqfxnwgrbdxeed2vv4a35vwe