Comparison of 3-D maximum a posteriori and filtered backprojection algorithms for high-resolution animal imaging with microPET

A. Chatziioannou, J. Qi, A. Moore, A. Annala, K. Nguyen, R. Leahy, S.R. Cherry
2000 IEEE Transactions on Medical Imaging  
We have evaluated the performance of two three dimensional reconstruction algorithms with data acquired from microPET, a high resolution tomograph dedicated to small animal imaging. The first was a linear filteredbackprojection algorithm (FBP) with reprojection of the missing data and the second was a statistical maximum-aposteriori probability algorithm (MAP). The two algorithms were evaluated in terms of their resolution performance, both in phantoms and in vivo. Sixty independent
more » ... of a phantom simulating the brain of a baby monkey were acquired, each containing 3 million counts. Each of these realizations was reconstructed independently with both algorithms. The ensemble of the sixty reconstructed realizations was used to estimate the standard deviation as a measure of the noise for each reconstruction algorithm. More detail was recovered in the MAP reconstruction without an increase in noise relative to FBP. Studies in a simple cylindrical compartment phantom demonstrated improved recovery of known activity ratios with MAP. Finally in vivo studies also demonstrated a clear improvement in spatial resolution using the MAP algorithm. The quantitative accuracy of the MAP reconstruction was also evaluated by comparison with autoradiography and direct well counting of tissue samples and was shown to be superior. Index Terms -Positron Emission Tomography, image reconstruction, small animal imaging.
doi:10.1109/42.870260 pmid:11021693 fatcat:rgqw56lxjze4nepzljfamxnhva