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Current procedures for inferring population history are generally performed under the assumption of complete neutrality - that is, neglecting both direct selection and the effects of selection on linked sites. We here examine how the presence of purifying and background selection may bias demographic inference by evaluating two commonly-used methods (MSMC and fastsimcoal2), specifically studying how the underlying shape of the distribution of fitness effects (DFE) and the fraction of directlydoi:10.1101/2020.04.28.066365 pmid:33501439 pmcid:PMC7836109 fatcat:c3cjdb2srjdrbin4l5fwciuiwy