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<p>Experimental acute ischemic stroke was modeled by bilateral occlusion of the common carotid arteries in rats. Antioxidant system in the brain tissue was evaluated by the activity of key enzymes of thiol and disulfide indicators<br />nitrosative stress. Simulation of acute ischemic accompanied by violation of the thiol-disulfide balance and increased nitrotyrosine levels, indicating that the development of oxidative and nitrosative stress in brain tissue. It is established<br />that the usedoi:10.11603/mcch.2410-681x.2015.v17.i4.5687 fatcat:hhjuzfpirrdmrn6feviqezwxbe