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Systems-based biological concordance and predictive reproducibility of gene set discovery methods in cardiovascular disease
2011
Journal of Biomedical Informatics
The discovery of novel disease biomarkers is a crucial challenge for translational bioinformatics. Demonstration of both their classification power and reproducibility across independent datasets are essential requirements to assess their potential clinical relevance. Small datasets and multiplicity of putative biomarker sets may explain lack of predictive reproducibility. Studies based on pathway-driven discovery approaches have suggested that, despite such discrepancies, the resulting
doi:10.1016/j.jbi.2011.02.003
pmid:21315182
fatcat:2rd2d6yiinhg5cadfkzobd3tyi