Leptin Concentrations in the Polycystic Ovary Syndrome

C. S. Mantzoros
1997 Journal of Clinical Endocrinology and Metabolism  
The polycystic ovary syndrome (PCOS) is characterized by menstrual disturbances, chronic anovulation and hyperandrogenism and is associated with insulin resistance and hyperinsulinemia. Leptin, the product of the ob gene, is an adipocyte-secreted molecule that signals the magnitude of energy stores to the brain and has been recently shown to have important effects on the reproductive axis of rodents. To assess the potential contribution of leptin to the pathogenesis of PCOS, we measured leptin
more » ... evels in 24 obese women with PCOS and 12 weight-and age-matched controls and determined whether alterations in hyperinsulinemia produced by administration of the insulin-sensitizing agent troglitazone had an effect on serum leptin levels. Leptin concentrations at baseline were not different in women with PCOS (38.1 Ϯ 2.15 ng/mL) and controls (33.12 Ϯ 2.39 ng/mL). Moreover, leptin concentrations remained unchanged after
doi:10.1210/jc.82.6.1687 pmid:9177364 fatcat:6ilve2b7cje7xazwabxjy6j5nq