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DNAscent v2: Detecting Replication Forks in Nanopore Sequencing Data with Deep Learning
[article]
2020
bioRxiv
pre-print
The detection of base analogues in Oxford Nanopore Technologies (ONT) sequencing reads has become a promising new method for the high-throughput measurement of DNA replication dynamics with single-molecule resolution. This paper introduces DNAscent v2, software that uses a residual neural network to achieve fast, accurate detection of the thymidine analogue BrdU with single-base resolution. DNAscent v2 comes equipped with an autoencoder that detects replication forks, origins, and termination
doi:10.1101/2020.11.04.368225
fatcat:4i7b5zawhzfcnk4f4vtli7jhce