Medical treatment as an alternative to adrenalectomy in patients with aldosterone-producing adenomas

A. Karagiannis, K. Tziomalos, A. I Kakafika, V. G Athyros, F. Harsoulis, D. P Mikhailidis
2008 Endocrine-Related Cancer  
Primary aldosteronism (PA) and, in particular, its two commonest subtypes (i.e. idiopathic hyperaldosteronism (IHA) and aldosterone-producing adenoma (APA)) have been recognized as the most common cause of secondary hypertension. While 'conservative' medical treatment with aldosterone receptor antagonists is the therapeutic approach of choice in controlling blood pressure in patients with PA due to IHA, the more invasive (laparoscopic) adrenalectomy seems to be the most suitable therapy for
more » ... ble therapy for patients with APA. In this review, we focus on the medical approach for the management of APA in cases where surgical excision of the adrenal is not possible. Endocrine
doi:10.1677/erc-08-0094 pmid:18586836 fatcat:d7ra7q5gyneotioxzgduid7ota