Quantification of adult cerebral hemodynamics by near-infrared spectroscopy

C. E. Elwell, M. Cope, A. D. Edwards, J. S. Wyatt, D. T. Delpy, E. O. Reynolds
1994 Journal of applied physiology  
Quantification of adult cerebral hemodynamics by near-infrared spectroscopy. J. Appl. Physiol. 77(6): 2753-2760, 1994.-Near-infrared spectroscopy was used to measure global cerebral blood flow and volume in 10 healthy adult volunteers. High-and low-cerebral blood flow compartments were detected with mean flows for all 10 subjects of 59 t 21 (SD) and 11 t, 4 ml. 100 g-' l min-', respectively. The mean cerebral blood volume of the group was 2.85 + 0.97 ml/l00 g. Analysis of spontaneous changes in
more » ... ntaneous changes in the cerebral concentrations of oxyhemoglobin and deoxyhemoglobin demonstrated strong correlations between respiratory rate and the oscillation frequency of cerebral oxyhemoglobin concentration (r = 0.99) and arterial oxygen saturation (SaoJ (r = 0.99). An estimate of the mean cerebral oxygen saturation for all subjects averaged 59.4 t 12.4% when their mean Saoz was 91.8 t 2.4% (equivalent to 67.6 t 13.8% at a normoxic Sao, of 98%). These results demonstrate that near-infrared spectroscopy can be used as a noninvasive bedside technique for both qualitative and quantitative evaluation of cerebral hemodynamics and oxygenation in adults. cerebral blood flow; cerebral blood volume; mean cerebral saturation
doi:10.1152/jappl.1994.77.6.2753 pmid:7896617 fatcat:wtptban57za2pg63vxgbuyus2y