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The hippocampus is critical for some forms of memory and spatial navigation, but previous research has mostly neglected the CA2, a unique region situated between CA3 and CA1. Here, we show that CA2 pyramidal neurons have distinctive physiological characteristics that include an unprecedented synaptic stability. Although basal synaptic currents in CA1 and CA2 are quite similar, synaptic plasticity including long-term potentiation and long-term depression is absent or less likely to be induceddoi:10.1523/jneurosci.4094-07.2007 pmid:17978044 pmcid:PMC6673350 fatcat:o7wdh4bdx5akfnlnvkemts42ze