Oxidized HDL, Adipokines, and Endothelial Dysfunction: A Potential Biomarker Profile for Cardiovascular Risk in Women with Obesity

Stephen J. Peterson, Joseph I. Shapiro, Ellen Thompson, Shailendra Singh, Lu Liu, Jeremy A. Weingarten, Kathleen O'Hanlon, Angelica Bialczak, Siddharth R. Bhesania, Nader G. Abraham
2018 Obesity  
High BMI predicts adverse cardiovascular outcomes and positively correlates with increased levels of adipokines. The relationship among BMI, IL-6, TNFα, adiponectin, and oxidized high-density lipoprotein (Ox-HDL) with circulating endothelial cells (CECs) and endothelial progenitor cells (EPCs) has not been well studied. Elevated CEC levels have been described in both humans and mice with obesity and diabetes. Ox-HDL has been shown to be a potent driver of adipogenesis in vivo and in vitro. In
more » ... is study, elevated BMI was examined in 2 groups of women studied in Brooklyn, New York, and Huntington, West Virginia, respectively.
doi:10.1002/oby.22354 pmid:30569635 pmcid:PMC6309990 fatcat:m33et7dhivb35b2xi3ykjjtmme