CODEN(USA): PCJHBA Design of Fast Dissolving Anti-Asthmatic Films Using 2 3 Factorial Designs

Rakesh Meel, C Chauhan
2016 The Pharmaceutical and Chemical Journal   unpublished
Fast dissolving films are playing an important role in the current pharmaceutical drug delivery systems. They have convenience and ease of use over solid and liquid dosage forms. In the present research, fast dissolving oral film of terbutaline sulphate were developed using HPMC K15 LV as film forming polymer. The films were prepared by solvent casting method. Optimization of HPMC E15 LV, SSG and PEG-400 was carried out using 2 3 full factorial designs. The formulated films of terbutaline
more » ... f terbutaline sulphate were evaluated for their physico-mechanical parameters like disintegration time, tensile strength, percent elongation, folding endurance and In-vitro drug release. Estimation of drug content uniformity of terbutaline sulphate films was performed and the results were satisfactory. Optimized batch F 6 has thickness (0.254±0.01mm), disintegration time (19.90±0.42 sec.) tensile strength (2.95±0.09 Mpa), % Elongation (18.95±0.12), Folding endurance (153±7.0), CPR 1min 35.16±4.56% and CPR 10min 80.29±4.15%.
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