Click chemistry approach to a series of calcitriol analogues with heterocyclic side chains

Zoila Gándara, Pedro-Lois Suárez, Alioune Fall, Massène Sène, Ousmane Diouf, Mohamed Gaye, Generosa Gómez, Yagamare Fall
2016 Mediterranean Journal of Chemistry  
We report a straightforward synthesis of a series of novel calcitriol analogues from vitamin D 2 with some modification of the procedures described by Calverley and Choudhry. This approach allows the large scale synthesis of a late-stage intermediate common to all the analogues of the series.This intermediate was successfully employed to synthesize a huge number of calcitriol analogues using a "click" chemistry approach.
doi:10.13171/mjc52/016041430/gomez/fall fatcat:moeuzy7y5jg25prbzvgschlena