Review question / Objective: We attempted to evaluate the effect of ITPA 94C>A p o l y m o r p h i s m o n 6 -M P -i n d u c e d hematological toxicity and hepatotoxicity through a systematic review and metaanalysis. Condition being studied: Completed analysis but not published -The results indicated that ITPA 94C>A was significantly associated with 6-MP-induced neutropenia (OR 2.38, 95% CI: 1.56-3.62; p = 0.005) and hepatotoxicity (OR 1.98, 95% CI: 1.32-2.95; p = 0.0009); however, no

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... t association was found between the ITPA 9 4 C > A v a r i a n t a n d 6 -M P -i n d u c e d INPLASY 1 International Platform of Registered Systematic Review and Meta-analysis Protocols INPLASY PROTOCOL Effect of ITPA polymorphism on adverse drug reactions of 6-mercaptopurine in pediatric patients with acute lymphoblastic leukemia: a systematic review and meta-analysis Lee, Y 1 ; Jang, EJ 2 ; Yoon, H-Y 3 ; Yee, J 4 ; Gwak, H-S 5 . To cite: Lee et al. Effect of ITPA polymorphism on adverse drug reactions of 6-mercaptopurine in pediatric patients with acute lymphoblastic leukemia: a systematic review and metaanalysis. Inplasy protocol 202220110.