The use of menopausal hormone therapy in women survivors of gynecological cancer: safety report based on systematic reviews and meta-analysis

2021 European Journal of Gynaecological Oncology  
The data collected during the last two decades on the effects of Hormonal menopause treatment (HMT) could help to provide a safer and more effective long term-treatment of menopause symptoms and possible complications such as osteoporotic fractures, cognitive impairment, or cardiovascular conditions, as well as an improved quality of life. Having a history of suffering from gynecological cancer (endometrial, cervical or ovarian) is one of the conditions that most strongly determines the use of
more » ... ny form of HMT due to the concerns associated with a possible recurrence of the disease. Objective: to create a set of eligibility criteria for the use of HMT in gynecological cancer patients. Methods: The study was registered in PROSPERO (registration number CRD42020166658). Results: Ovarian cancer survivors who use HMT have better overall survival, disease-free survival, and lower recurrence rates than women survivors who do not use HMT. Endometrial cancer survivors who use HMT do not have a higher rate of disease recurrence than those survivors who do not use HMT. Cervical cancer survivors who use HMT do not have a higher rate of disease recurrence than those survivors who do not use HMT. Conclusion: HMT is safe in women who have suffered from most of non-advanced gynecological cancers.
doi:10.31083/j.ejgo4205155 fatcat:ousbyr4ym5gx7nzktqnlm4kdre