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Despite its great promise, neuroimaging has yet to substantially impact clinical practice and public health. However, a developing synergy between emerging analysis techniques and data-sharing initiatives has the potential to transform the role of neuroimaging in clinical applications. We review the state of translational neuroimaging and outline an approach to developing brain signatures that can be shared, tested in multiple contexts and applied in clinical settings. The approach rests ondoi:10.1038/nn.4478 pmid:28230847 pmcid:PMC5988350 fatcat:53smgjswmbea3ingvpjhqy6oha