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Healthcare is an increasingly collaborative enterprise involving many individuals and organizations that coordinate their efforts toward promoting quality and efficient delivery of healthcare through the use of interoperable healthcare information systems. This paper presents a mediator-based approach for achieving data and service interoperability among disparate and geographically dispersed healthcare information systems. The proposed system architecture enables decoupling of the clientpmid:19745293 fatcat:zduqqohiujbmpcmvmkg5vffgsi