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Isosorbide mononitrate promotes angiogenesis in embryonic development of zebrafish
2020
Genetics and Molecular Biology
Coronary heart disease (CHD) is a leading cause of death worldwide, and angiogenesis plays important roles in CHD. Thus, in the present study, the angiogenic efficacy of four common cardiovascular medicines (aspirin, pravastatin, metoprolol and isosorbide mononitrate (ISMN)) was determined by the number and length of zebrafish intersegmental vessels (ISVs) after immersing zebrafish embryos in different medicines. Results showed that ISMN significantly increased the length and number of ISVs.
doi:10.1590/1678-4685-gmb-2019-0233
pmid:32706844
fatcat:afykbnokbvfznl7xq5uc2ti6fy