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With the growth of biological data in volume and heterogeneity, web search engines become key tools for researchers. However, general-purpose search engines are not specialized for the search of biological data. Description: Here, we present an approach at developing a biological web search engine based on the Semantic Web technologies and demonstrate its implementation for retrieving gene-and protein-centered knowledge. The engine is available at http://www.integromedb.org. Conclusions: Thedoi:10.1186/1471-2164-13-35 pmid:22260095 pmcid:PMC3293773 fatcat:wrjk3un4urf2vd3psw4xpvozoe