Computational neuroscience models can be used to understand neural dynamics in the brain and these dynamics change as the physiological and other conditions like aging. One such approach we have used in this work is Energy Landscape analysis based on resting-state fMRI data. The dataset consists of 70 subjects with normal cognitive function, of which 23 are young adults and 47 are old adults. In this analysis, disconnectivity graphs and activity patterns are generated and using connectivity

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... istics among seven prominent brain networks. To study brain dynamic behaviors, we perform sliding window studies on the dataset and observe local minima of each window evolving in time. By varying the window shift from multiple seconds to 1 second, we can obtain statistics and evaluate the speed and activity pattern holding time of individual and group subjects. We found that older subjects can hold the brain states for a longer time but then jump to other dominated brain state local minima with a large hamming distance, whereas young subjects change dominated local minima more frequently but with a small hamming distance of 1 or 2. In fact, when averaged over the full time course, old subjects have more stable brain states local minima compared to young subjects. For both young and old subjects, the default mode network (DMN) and visual network (VIS) are coupled but for young subjects the two networks are on and off together and strongly correlated. For old subjects, there is an extra dominated brain state local minimum that the DMN and attention network (ATN) are correlated and anti-correlated with (VIS) and sensory-motor networks (SMN). This state may suggest old subjects are more capable of focusing on brain internal models and not getting influenced by external visual and sensory factors than young subjects.