The prevalence and socio-demographic factors of peptic ulcer disease (PUD) have changed remarkably now a day. Currently, peptic ulcer disease has considered as a multifactorial health problem. Objective: To determine the socio-demographic factors of Peptic ulcer disease among patients attending Bangladesh Medical College, Dhanmondi, Dhaka, Bangladesh. Methods: This is a hospital-record based cross sectional descriptive study executed in a tertiary care teaching hospital, Dhanmondi, Dhaka. The

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... udy group comprises 200 PUD patients enrolled in our Bangladesh Medical College Hospital from July 2019 to December 2020. Analysis of data was done by using SPSS 15 software. Prevalence of PUD patients among study population was calculated by using percentage and the strength of association of socio- demographic factors were evaluated in our study. Results: Total prevalence of PUD among the studied group was 83.5%; gastric ulcer 54.5% and duodenal ulcer 29%. Majority 56% were female patients in the age group of 41-50 years. Most prevalent endoscopic finding was erosive antral gastritis (48.50%). PUD was diagnosed predominantly among unemployed population (48.50%) in the urban locality (62%). The cardinal features were pain precipitated by certain food (55.69%) and loss of appetite (52. 09%).Regarding risk factors spicy food (55.69%) has secured the first position in our study followed by smoking (34.13%) and stress (18.56%). Conclusion: Multifactorial variables were considered as risk factors for PUD. Population based endoscopic studies can detect PUD at its earliest possible stage and create awareness among population to prevent its further progression.